On offense, New York erupted for 358 total yards and 8.7 yards per play in the second half against the Cardinals last week and is converting nearly 43% of third down chances through two weeks. New York was in the top five in third down efficiency allowed (35.1%) and red zone efficiency allowed (49.2%) last season and allowed only 6.9 yards per attempt with 41 sacks last year. The Giants have given up only 322.0 total yards per game, and that builds off a strong 2022 performance in key metrics. The Giants are in the top 10 of the NFL in passing defense through two weeks, yielding only 187.5 yards per game, and opponents have only one passing touchdown against New York. New York's defense showed tangible improvement in the second half of Week 2, helping to boost the team to a comeback win.

SF: 49ers are 14-8 against the spread in the last 22 games.

NYG: Giants are 14-7 against the spread in the last 21 games.

Giants money line: 49ers -550, Giants +410 Now, here are several NFL odds and betting lines for Giants vs. You can head to SportsLine to see his picks.

Giants and just locked in his picks and TNF predictions. He's also uniquely dialed into the San Francisco 49ers, with a 17-5 run on his against-the-spread NFL picks involving the Niners that has returned $1,150 to bettors. Armed with an elaborate network of sources, Roberts has unmatched info in multiple sports. Roberts has worked in the Las Vegas sportsbook industry for more than 20 years, including a 13-year run as Station Casinos' book director. 49ers picks or NFL predictions, be sure to see what SportsLine's resident Niners expert, Micah Roberts, has to say, considering his mastery of picks involving San Francisco. San Francisco is a 10.5-point favorite, while the over/under, or total number of points Vegas thinks will be scored, is 44 in the latest 49ers vs.

New York is 1-1 this season, with a blowout loss to Dallas in the opener and a comeback win over Arizona in Week 2.

This tilt is also the home opener for the 49ers after back-to-back road wins. Kyle Shanahan and the 49ers have won 12 consecutive regular season games, and the 49ers will host the New York Giants in Week 3. The San Francisco 49ers will try to continue a historic streak when they take the field on Thursday Night Football.

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